Staff Profile

Dr Nikos Mardas

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Personal Profile

Name: Nikos Mardas Email: n.mardas@ucl.ac.uk
Title: Dr Tel: 020 7915 2379
Department: Restorative Dental Sciences Fax: 020 7915 1137
Position: Senior Clinical Lecturer Address: UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD
Research Domain: Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

Profile

Research Description

My main research interests are in the area of tissue regeneration and wound healing, utilising various barriers according to the GTR principle, various bone grafts and bone substitutes, bone morphogenetic proteins, growth factors and cell bio-technology. I have a special interest on the outcome of the above mentioned treatment principles in specific systemic conditions like osteoporosis. For the last 7 years, I have been actively involved in several original research projects, including in vitro biomaterial testing and development, preclinical - animal experimental projects and randomised clinical trials, evaluating the effectiveness of new regenerative materials for bone and periodontal regeneration, as well as dental implant related treatment protocols. My future research perspectives are dealing with the development of tissue regeneration protocols based on the combination of novel biomaterials / scaffolds for growth factor, cell or chemotherapeutics delivery and the already existing bone and periodontal tissue regeneration principles, such as GTR that could be applied in either healthy or systemically compromised individuals. The creation of a sound scientific link between in-vitro studies, pre-clinical animal experiments and initial clinical trials evaluating this -tissue engineering based- treatment approach, constitute my main long term research target. Furthermore, I have been involved in the design of preclinical and clinical trials investigating: • The influence of genetic, environmental factors, (e.g. smoking, osteoporosis) on periodontal, and implant wound healing • The effectiveness and predictability of conventional, regenerative periodontal surgical treatment and implant treatment modalities in specific categories of patients like diabetic and osteoporotic patients. • The effectiveness of new regenerative materials for bone and periodontal regeneration as well as new dental implants in controlled preclinical experiments and randomised clinical trials. • The evaluation of different types of periodontal surgery in terms of clinical and patient based outcomes

Research Activities

Education Description

Dr Mardas is the Programme Coordinator for the MSc and MClinDent in Periodontology.

UCL Collaborators

External Collaborators

Publications

    2013

    • Patel K, Mardas N, Donos N (2013). Radiographic and clinical outcomes of implants placed in ridge preserved sites: a 12-month post-loading follow-up.. Clin Oral Implants Res, 24(6), 599 - 605. doi:10.1111/j.1600-0501.2012.02500.x
    • Horváth A, Mardas N, Mezzomo LA, Needleman IG, Donos N (2013). Alveolar ridge preservation. A systematic review. Clinical Oral Investigations, 17(2), 341 - 363.
    • Horváth A, Mardas N, Mezzomo LA, Needleman IG, Donos N (2013). Alveolar ridge preservation. A systematic review.. Clin Oral Investig, 17(2), 341 - 363. doi:10.1007/s00784-012-0758-5
    • Patel K, Mardas N, Donos N (2013). Radiographic and clinical outcomes of implants placed in ridge preserved sites: A 12-month post-loading follow-up. Clinical Oral Implants Research, 24(6), 599 - 605.

    2012

    • Dereka X, Mardas N, Chin S, Petrie A, Donos N (2012). A systematic review on the association between genetic predisposition and dental implant biological complications.. Clin Oral Implants Res, 23(7), 775 - 788. doi:10.1111/j.1600-0501.2011.02329.x
    • Mardas N, Kraehenmann M, Dard M (2012). Regenerative wound healing in acute degree III mandibular defects in dogs.. Quintessence Int, 43(5), e48 - e59.
    • Dereka X, Mardas N, Chin S, Petrie A, Donos N (2012). A systematic review on the association between genetic predisposition and dental implant biological complications. Clinical Oral Implants Research, 23(7), 775 - 788.
    • Furze D, Byrne A, Donos N, Mardas N (2012). Clinical and esthetic outcomes of single-tooth implants in the anterior maxilla.. Quintessence Int, 43(2), 127 - 134.
    • Donos N, Laurell L, Mardas N (2012). Hierarchical decisions on teeth vs. implants in the periodontitis-susceptible patient: the modern dilemma.. Periodontol 2000, 59(1), 89 - 110. doi:10.1111/j.1600-0757.2011.00433.x
    • Zambon R, Mardas N, Horvath A, Petrie A, Dard M, Donos N (2012). The effect of loading in regenerated bone in dehiscence defects following a combined approach of bone grafting and GBR.. Clin Oral Implants Res, 23(5), 591 - 601. doi:10.1111/j.1600-0501.2011.02279.x

    2011

    • Mezzomo LA, Shinkai RS, Mardas N, Donos N (2011). Alveolar ridge preservation after dental extraction and before implant placement: A literature review. Revista Odonto Ciencia, 26(1), 77 - 83.
    • Donos N, Graziani F, Mardas N, Kostopoulos L (2011). The use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects.. Clin Oral Implants Res, 22(12), 1346 - 1353. doi:10.1111/j.1600-0501.2010.02120.x
    • Gellynck K, Neel EA, Li H, Mardas N, Donos N, Buxton P, Young AM (2011). Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine.. Acta Biomater, 7(6), 2672 - 2677. doi:10.1016/j.actbio.2011.02.033
    • Liñares A, Mardas N, Dard M, Donos N (2011). Effect of immediate or delayed loading following immediate placement of implants with a modified surface.. Clin Oral Implants Res, 22(1), 38 - 46. doi:10.1111/j.1600-0501.2010.01988.x
    • Mardas N, D'Aiuto F, Mezzomo L, Arzoumanidi M, Donos N (2011). Radiographic alveolar bone changes following ridge preservation with two different biomaterials. CLIN ORAL IMPLAN RES, 22(4), 416 - 423. doi:10.1111/j.1600-0501.2010.02154.x
    • Mardas N, Schwarz F, Petrie A, Hakimi AR, Donos N (2011). The effect of SLActive surface in guided bone formation in osteoporotic-like conditions.. Clin Oral Implants Res, 22(4), 406 - 415. doi:10.1111/j.1600-0501.2010.02094.x

    2010

    • Mardas N, Chadha V, Donos N (2010). Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial. Clinical Oral Implants Research, 21(7), 688 - 698.

    2009

    • Liñares A, Mardas N, Obrecht M, Dard M, Donos N (2009). Bone healing following immediately placed and loaded implants in minipigs.
    • Mardas N, D'Aiuto F, Arzomanidi M, Donos N (2009). Radiographic alveolar bone changes after ridge preservation with two different biomaterials.
    • Donos N, Mardas N, Buser D, 1st European Consensus Workshop in Implant Dentistry University Education (2009). An outline of competencies and the appropriate postgraduate educational pathways in implant dentistry.. Eur J Dent Educ, 13 Suppl 1, 45 - 54. doi:10.1111/j.1600-0579.2008.01528.x
    • Donos N, Mardas N, Buser D (2009). An outline of competencies and the appropriate postgraduate educational pathways in implant dentistry. European Journal of Dental Education, 13(Suppl. 1), 44 - 54.

    2008

    • Mardas N, Stavropoulos A, Karring T (2008). Calvarial bone regeneration by a combination of natural anorganic bovine-derived hydroxyapatite matrix coupled with a synthetic cell-binding peptide (PepGen™): an experimental study in rats. Clinical Oral Implants Research, 19(10), 1010 - 1015.
    • Tonetti MS, Hämmerle CHF, Abrahamsson I, Becker J, Blanco J, Botticelli D, Donos N, Giannobile W, Jung R, Mardas N, Neukam E, Parlar A, Pjetursson B, Rocchietta I, Simion M, Stavropoulos A, Thoma D (2008). Advances in bone augmentation to enable dental implant placement: Consensus Report of the Sixth European Workshop on Periodontology. Journal of Clinical Periodontology, 35(Suppl. 8), 168 - 172.
    • Donos N, Mardas N, Chadha V (2008). Clinical outcomes of implants following lateral bone augmentation: systematic assessment of available options (barrier membranes, bone grafts, split osteotomy). Journal of Clinical Periodontology, 35(Suppl. 8), 173 - 202.
    • Mardas N, Chadha V, Donos N (2008). Socket preservation with synthetic bone substitute or a bovine xenograft.

    2007

    • Mardas N, Kraehenmann M, Dard M, Donos N (2007). Periodontal regeneration of degree III furcation defects with Emdogain Plus.

    2006

    • Mardas N, Stavropoulos A, Karring T (2006). Anorganic bovine-derived hydroxyapatite matrix coupled with a synthetic cell-binding peptide (PepGen P-15) for bone regeneration.
    • Mardas N (2006). Guided bone regeneration in bone defects associated with dental implants (part two). Private Dentistry, 11(2), 18 - 23.
    • Mardas N (2006). Guided bone regeneration in bone defects associated with dental implants. Private Dentistry, 11(1), 24 - 33.

    2005

    • Mardas NC (2005). Bone formation with guided tissue regeneration and demineralized bone matrix.
    • Mardas NC (2005). Knogleregeneration med styret vaevsregeneration og demineraliseret knoglematriks. Tandlaegebladet, 109(11), 896 - 897.

    2004

    • Stavropoulos A, Mardas N, Herrero F, Karring T (2004). Smoking affects the outcome of guided tissue regeneration with bioresorbable membranes: a retrospective analysis of intrabony defects. Journal of Clinical Periodontology, 31(11), 945 - 950.

    2003

    • Mardas N, Kostopoulos L, Stavropoulos A, Karring T (2003). Osteogenesis by guided tissue regeneration and demineralized bone matrix. Journal of Clinical Periodontology, 30(3), 176 - 183. doi:10.1034/j.1600-051X.2003.20031.x
    • Stavropoulos A, Mardas N, Karring T (2003). Long-term stability of PAL-gain achieved by guided tissue regeneration with resorbable membranes - Results after 1 and 6-7 years.. J DENT RES, 82, B385 - B385.
    • Stavropoulos A, Mardas N, Karring T (2003). Long-term stability of PAL-gain achieved by guided tissue regeneration with resorbable membranes - results after 1 and 6-7 years.
    • Stavropoulos A, Kostopoulos L, Mardas N, Karring T (2003). Influence of demineralized bone matrix's embryonic origin on bone formation: an experimental study in rats. Clinical Implant Dentistry and Related Research, 5(3), 184 - 192.
    • Stavropoulos A, Kostopoulos L, Mardas N, Nyengaard JR, Karring T (2003). Gentamicin used as an adjunct to GTR. An experimental study in rats. Journal of Clinical Periodontology, 30(5), 454 - 461.
    • Stavropoulos A, Kostopoulos L, Mardas N, Nyengaard JR, Karring T (2003). Gentamicin used as an adjunct to GTR.. J Clin Periodontol, 30(5), 455 - 462.
    • Stavropoulos A, Kostopoulos L, Mardas N, Nyengaard JR, Karring T (2003). Gentamicin used as an adjunct to GTR. J CLIN PERIODONTOL, 30(5), 454 - 461.
    • Mardas N, Kostopoulos L, Stavropoulos A, Karring T (2003). Denaturation of demineralized bone matrix significantly reduces bone formation by guided tissue regeneration. Clinical Oral Implants Research, 14(6), 804 - 811. doi:10.1046/j.0905-7161.2003.00965.x
    • Mardas N, Kostopoulos L, Stavropoulos A, Karring T (2003). Evaluation of a cell-permeable barrier for guided tissue regeneration combined with demineralized bone matrix. Clinical Oral Implants Research, 14(6), 812 - 818. doi:10.1046/j.0905-7161.2003.00966.x

    2002

    • Mardas N, Kostopoulos L, Karring T (2002). Bone and suture regeneration in calvarial defects by e-PTFE-membranes and demineralized bone matrix and the impact on calvarial growth: an experimental study in the rat. Journal of Craniofacial Surgery, 13(3), 453 - 464.

    2001

    • Stavropoulos A, Kostopoulos L, Mardas N, Nyengaard JR, Karring T (2001). Deproteinized bovine bone used as an adjunct to guided bone augmentation: an experimental study in the rat. Clinical Implant Dentistry and Related Research, 3(3), 156 - 165.

    2000

    • Mardas N, Kostopoulos L, Stavropoulos A, Karring T (2000). The importance of the osseoinductive properties of DBM for bone formation by GTR. J DENT RES, 79, 624 - 624.
    • Stavropoulos A, Kostopoulos L, Mardas N, Nyengaard JR, Karring T (2000). Bio-Oss (R) delays bone formation when used as adjunct to GTR.. J DENT RES, 79, 155 - 155.

    1998

    • Mardas N, Kostopoulos L, Karring T (1998). Calvarial bone and suture regeneration by GTR and DBM and its impact on growth of the calvarium.. J DENT RES, 77, 775 - 775.